The Academy of Science of South Africa (ASSAf), and the South African Young Academy of Science (SAYAS), in partnership with the World Academy of Science sub-Saharan Africa Regional Partner (TWAS-SAREP), the Human Sciences Research Council (HSRC), the National Research Foundation (NRF) and the South African National Space Agency (SANSA), will jointly host the Annual Young Scientists’ Conference (AYSC) on 13-14 October 2025. ASSAf and its partners invite applications from young scientists based in South Africa and across Sub-Saharan Africa to participate in the 2025 AYSC. This transdisciplinary conference will serve as a platform for scientific exchange, through collaboration, networking, and knowledge sharing among young African researchers from diverse fields. The conference will feature the following sub-themes: Resilience in Adaptation and Mitigation: A Holistic Approach,  Climate Change Impact on Human and Planetary Health, Equity in Climate Action.